Multimorbidity could cause a healthcare crisis – here’s what we can do about it

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Older patients often suffer from multiple conditions.
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Professor Chris Salisbury profile picture

Professor Chris Salisbury, Primary Health Care, University of Bristol

Multimorbidity is one of the biggest challenges facing healthcare. In recent years, a succession of research studies have shown that people with multiple health problems are more likely to have a worse quality of life, worse mental health and reduced life expectancy. The more health problems someone has, the more drugs they are likely to be prescribed and the more frequently they are likely to consult a GP or be admitted to hospital.

You might think this is all rather self-evident – it’s hardly a surprise that sick people get ill, take medicines and go to doctors more often than healthy people.

So why has multimorbidity become so prominent in discussions about healthcare over the last decade?

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Statins and venous thromboembolism: should statins use extend beyond lowering cholesterol?

Setor Kunutsor profile picture

Dr Setor Kunutsor, Research Fellow in Evidence Synthesis/ Epidemiologist, School of Clinical Sciences, University of Bristol

Statins are well known and established for their role in the prevention of cardiovascular disease (heart attack, strokes, or angina) and this is based on their ability to lower levels of cholesterol in the blood.

However, there is evidence to suggest that statins have multiple effects and these include potential beneficial impacts on other disease conditions.

Venous thromboembolism is a condition involving the formation of blood clots in the veins of the lungs and lower limbs. It affects millions of people globally and is a preventable cause of hospital-related deaths.

Standard techniques for the prevention of venous thromboembolism include the use of elastic stockings, compression devices, patient mobility and rehabilitation, and anticoagulant therapy (blood thinning medications).

Blausen 0290 DeepVeinThrombosis

Deep Vein Thrombosis. Blausen.com staff (2014). “Medical gallery of Blausen Medical 2014“. WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.010.  ISSN 2002-4436

Evidence now suggests that statins also have the ability to reduce inflammation in the body and prevent the formation of blood clots. Based on these properties, there have been suggestions that statins may prevent venous thromboembolism.

Several studies have investigated this, however the evidence has not been conclusive until now.

We decided it was time to bring all the evidence together and evaluate if statins really did have a protective effect on the risk of developing venous thromboembolism.

Altogether we analysed 36 studies (13 observational cohort designs and 23 randomised controlled trials) with data on more than 3.2 million participants.

Our results showed a clear link between the use of statins and a reduced risk of developing venous thromboembolism. Continue reading

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If academics are serious about research impact they need to learn from monitoring, evaluation and learning teams

The impact of academic research, particularly on policy and the private sector, is an increasingly important component of research assessment exercises and funding distribution. However, Duncan Green argues that the way many researchers think about their impact continues to be pretty rudimentary. A lack of understanding of who key decision-makers are, a less-than-agile response to real-world events, and difficulties in attributing credit are all hampering progress in this area. Looking at how impact is measured by aid agencies, there is much academics could learn from their monitoring, evaluation and learning teams.

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Global Health: Antibiotics and Superbugs

In 1928 Alexander Fleming discovered penicillin, thus bringing one of the greatest medical advances of our time: antibiotics.

Innocuous infections, operations and injuries were no longer a death sentence.

Since then, antibiotics have been developed to treat an array of diseases but this slowed, and then stopped in the 1980s. Although our arsenal of development ceased, the bacteria, viruses and fungi did not stop evolving.

This asymmetric development has resulted in an antimicrobial resistance problem: bacteria causing common infections and illnesses are now increasingly resistant to the drugs used to treat them.

By 2050, the death toll could be a staggering one person every three seconds if AMR is not tackled now. Infographic from the AMR review

Creative Commons Attribution 4.0 International Public License. Attribution notice: ‘Review on Antimicrobial Resistance.’ From the O’Neill Report in 2016.

Solving this issue is not straightforward.

It involves a complex landscape of policy makers, clinicians, vets, law makers, and many others.

As part of Bristol Doctoral College’s Research without Borders Festival 2017, a public discussion was held exploring the problem of superbugs and antibiotic resistance, in both the context of research happening at the university of Bristol, and from a wider perspective.

Discussions revolved around patent law, and how it may affect development of new drugs and solutions, the role of agriculture, in particular dairy farming, in reducing antimicrobial resistance, and what we can do as individuals to help address this problem.

Below is a brief snapshot of the research relating to antimicrobial resistance being undertaken across the University of Bristol by the postgraduate researchers who took part in the RWB discussion panel. Continue reading

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It’s time to put mature students at the heart of widening participation

Why should we care about mature students?

It has become almost routine to read stories giving ‘more bad news’ about part-time student numbers in universities.

Tom Sperlinger is Reader in English Literature and Community Engagement at the University of Bristol.

Lizzie Fleming is Widening Participation and Student Recruitment Officer, and a postgraduate student, at the University of Bristol

On 29 June, the Office for Fair Access (OFFA), which monitors access to universities in the UK, published its outcomes for 2015-16. The report highlights a ‘crisis’ in part-time numbers, which have fallen for a seventh consecutive year, a decline of 61% since 2010-11. Since more than 90% of part-time students are over 21, this has also led to a significant decline in the number of mature students in the sector.

This also means that, overall, the number of students entering universities has fallen significantly since 2012. Continue reading

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Scoping the impact of Brexit for NHS procurement

Dr Albert Sanchez Graells, Senior Lecturer in Law, University of Bristol Law School

Dr Albert Sanchez Graells, Senior Lecturer in Law, University of Bristol Law School

NHS England spends over £20 billion every year on goods and services. A significant part of the remainder of NHS non-salary budget involves the commissioning of health care services. This expenditure and commissioning is controlled by NHS procurement rules, which in part derive from EU law. NHS procurement rules are regularly criticised for imposing excessive red tape and compliance costs, and calls for NHS procurement reform to free it from such strictures are common.

In this context, Brexit could be seen as an opportunity to overhaul NHS procurement and to move away from the perceived excesses of EU law. This post concentrates on two issues. First, does EU law prevent significant reforms of NHS procurement and, if so, can Brexit suppress such constraints? Second, is the way Brexit is unfolding conducive to an improvement of NHS procurement? Continue reading

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Why healthcare services have a problem with gambling

Image of electronic gambling machines.

“I have a problem with gambling. There’s not enough of it.”

Dr  Sean Cowlishaw, Research Fellow at the Centre for Academic Primary Care, University of Bristol

That was the admission from billionaire Steve Wynn, a major figure in the casino industry, speaking at a recent gambling research conference in (where else?) Las Vegas. And sure, it made for a good quote. But it’s also a rather glib dismissal of a serious issue that affects many thousands of people across the world.

The UK certainly has a problem with gambling. At least it has since 2007, when laws were changed to allow for huge growth in gambling opportunities and exposure. It has been hard to ignore the subsequent explosion in industry advertising, which increased by around 500% between 2007 and 2013. By contrast, you may have missed the increased numbers of high intensity electronic gambling machines, called Fixed-Odds Betting Terminals (FOBTs), which now occupy the high street (within betting shops) and allow punters to wager up to £100 every 20 seconds.

Yet Britain doesn’t have much insight into its problem with gambling. Compared to most other addictive behaviours, involving drugs or alcohol for example, gambling is largely ignored by health services and public health agencies. This is partly because gambling is a hidden concern. It does not manifest with physical warning signs. Indicators are usually visible in extreme cases only, and generally following major life crises such as extreme debt or relationship breakdown. Continue reading

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The 2017 General Election: first thoughts

Dr Hugh Pemberton
Reader in Contemporary British History, University of Bristol, Department of History

Writing on the morning after the election, the fog of war has lifted to reveal a battlefield on which all sides are claiming victory but nobody has actually won.

Others more prescient than me wondered before the election if it did not have a whiff of another ‘snap election’ – 1974.

It turns out they were right.

Then Ted Heath went to the country to secure a strong mandate to deal with an issue of national importance (in those days, union power) but found that he ended up with fewer not more MPs.

Ted held on in No.10 for a while but eventually Labour formed a minority government.

But the arithmetic and the politics this time are not those of 1974.

Screenshot of UK General Election 207 results, taken from BBC News website.

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The General Election 2017: national security, deradicalisation, and citizenship

As we head into the elections this Thursday, national security is a burning issue. The UK has been the target of three major terrorist attacks in the past few months. The latest attack in London comes within just two weeks of the bombing in Manchester last month. The involvement of British nationals in perpetrating these attacks has brought many questions about extremism, radicalisation and integration to the forefront.

Dr Devyani Prabhat, Lecturer in Law, Bristol School of Law

Party leaders are laying out their strategies for counter-terrorism. Theresa May has announced plans to set up a new counter-terrorism agency, monitor social media and web content for extremism, have stronger custodial sentences for terrorism, and work on integration of communities. Meanwhile Jeremy Corbyn has focused on the problems of British foreign policy, funding for terrorist activities, and the lack of policing resources. These plans are not reflected in their respective party manifestos and do not engage directly with the issue of alienated citizens. In fact, Prevent, a mainstay of counter-terrorism, is not even mentioned in the Conservative party manifesto, while the Labour manifesto merely mentions a review of Prevent. Both major parties are, however, likely to comprehensively rethink the current Prevent programme in light of the recent attacks. The Liberal Democrats and Green Party have already announced plans to replace Prevent. When such replacement or revision takes place, parties need to consider why minority citizens can become alienated and what British citizenship means to them as part of long term deradicalisation programmes. Continue reading

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Manifesto promises on pensions

Image with an old persons hand, the image is split with a zip and behind it is coins and money.

Dr Hugh Pemberton
Reader in Contemporary British History, University of Bristol and lead –  Thatcher’s Pension Reforms project.

The most dull and predictable general election in modern British history has its interesting aspects. First, it may mark a turning point in the major parties’ ideological stances. Second, it may mark a return to two-party politics (with polls indicating around 4 in 5 votes will go to one of the two main political ).

In the arena of pensions policy, Labour offers much more to voters than do the Conservatives.

Labour’s promises on pensions

Labour’s manifesto is its longest ever, packed with policy proposals and spending promises – not least on pensions – to be funded by higher taxes on the better off and on companies in a faster growing economy. Continue reading

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