It is perhaps a cruel irony that, on the same day the Intergovernmental Panel on Climate Change released a landmark call for urgent action, Jair Bolsonaro surged to victory in the first round of Brazil’s presidential elections. Although the leader of the far-right Partido Social Liberal did not achieve the 50% of the popular vote required to win outright, and will now have a run-off against Fernando Haddad of the Partido dos Trabalhadores (Workers’ Party), his rise has posed some painful and divisive questions both within Brazil and beyond. Continue reading
As many as 800,000 people around the world die every year by suicide, with 76% of these deaths in low and middle income countries like India and China. Between 110,000 and 168,000 people die from self-poisoning using pesticides – the same pesticides which are banned in wealthier countries due to human health and environmental concerns. Continue reading
The international community has widely acknowledged the severe threats posed by the impacts of climate change to a series of human rights, including the rights to life, health, and an adequate standard of living. But a stark gap has emerged between this acknowledgement in global climate policy – evidenced by a non-binding clause in the preamble of the Paris Agreement – and their actions to meet promised targets. Continue reading
We know that comparatively disadvantaged people, even in rich countries, have worse health and shorter life expectancy than others. But what is it exactly about socioeconomic disadvantage and other environmental difficulties that affects our biology? And at what age are we most vulnerable to these effects? Continue reading
Blog post by Dr Sumita Mukherjee, Senior Lecturer in History, discussing the roles of history and race in global suffrage.
In February 2018, I held a workshop in parliament to discuss the ways in which we could learn from the history of suffrage struggles, and the fights for political representation in the Global South, and use those lessons in reflecting on the centenary of the Representation of the People Act in Britain. The workshop was supported by PolicyBristol, History&Policy and the national Vote 100 campaign. Some of the podcasts from this event are available online. Speakers came from a range of academic and policy backgrounds, with an equally mixed audience. Continue reading
Controversial changes to disability welfare benefits have left many ill and disabled people unable to access the support they need. In his speech to the Labour Party conference, the party’s leader Jeremy Corbyn, spoke of how benefit assessments had “created a ‘hostile environment’ for disabled people”. Continue reading
When the NHS turned 70 this year, I was reminded of another anniversary which has had an enormous impact on healthcare over many years. Penicillin is 90 this year.
Discovered in September 1928 by Alexander Fleming, it was first used as a cure when George Paine treated eye infections with it in 1930. A method for mass production was devised by Howard Florey and Ernst Chain in 1940, and it was first mass produced in 1942, with half of that total supply used for one patient being treated for streptococcal septicaemia. Continue reading
Dr Sofia Galani, Lecturer in Law, University of Bristol Law School
A quick internet search for human rights in the first week of August retrieved results about the crucifixion of convicted criminals in Saudi Arabia and the political stand-off with Canada, the struggle of Argentinian women to decriminalise abortion and the debate on religion freedom sparked by Boris Johnson’s derogatory comments about women wearing burqas.
With all these human rights debates around us, it is not difficult to understand why we have not considered the human rights violations that take place in the maritime domain. Continue reading
Your body mass index (BMI) indicates whether you are within a healthy weight range based on your height. Having a higher BMI – meaning more weight relative to height – can increase your risk of developing heart disease, cancer and type 2 diabetes. While BMI is partly determined by your environment and lifestyle – including your diet and how much you exercise – our genes also play a role.
Genes are inherited from our parents. When this genetic information from the egg and sperm combine, the DNA is replicated continuously – doubling the number of cells until an entire baby is formed. DNA replication is not perfect and every single base in the human genome – the single blocks of code which make up entire DNA strand – has the potential to be mutated for good or for bad. Importantly, this creates a huge amount of random genetic variation at a population level, which is like a huge natural genetic experiment. If we know that these random genetic changes are linked to small changes in BMI, we can test whether BMI influences lots of different things, including cardiovascular health – like a randomized controlled trial.
Broadly, there are two ways of identifying parts of our DNA which are linked with particular traits. Studies of patients affected by rare obesity-related disorders (candidate gene studies) or large-scale population-based genome-wide association studies (GWAS). Findings from the latter of these methods – studies that look to see whether a change at any position in our DNA is linked with a particular trait – have implicated hundreds of common genetic variants associated with BMI.
A 2015 study conducted by the Genetic Investigation of Anthropometric Traits (GIANT) consortium and published in Nature found 97 places in our DNA which influence BMI levels and which were responsible for small differences between people, regardless of how different their environment and lifestyles were. This means that, while we cannot predict an individual’s BMI with genetics, we can refer to genetics to understand if patterns materialise in populations.
Small, genetically driven changes in BMI provide an opportunity to determine whether differences in BMI between people have a role in health and disease. Genetic mutations which are randomly allocated at conception aren’t easily changed by our environment and experiences later in life. As a result, our BMI, weight and chances of developing obesity-related diseases could partly be determined before we’re even born.
Low BMI, low heart disease risk
Using this property of genetic variation, we undertook a study that was recently published in the scientific journal Circulation. Our research showed that higher BMI is likely to have an influence on measures of cardiovascular health, such as blood pressure, in more than 3,000 healthy 17-year olds from the Avon Longitudinal Study of Parents and Children (also known as the Children of the 90s).
The Children of the 90s study, based in Bristol, has followed families in the UK through data collected from questionnaires, clinics and biological samples since the early 1990s. Using MRI scans from 400 21-year old Children of the 90s participants, who were recruited based on genetically driven differences in BMI, we also demonstrated that having a higher BMI is likely to lead to structural damage to heart tissue, including an enlarged left ventricle – the heart’s main pumping chamber.
Until now, studies have typically looked at the link between BMI and cardiovascular health in adults by observing patterns within populations. However, it’s difficult to conclude a relationship between the two without confusing the role that lifestyle factors play or finding how cardiovascular disease changes BMI rather than the reverse. Surveying people is also open to many sources of bias, such as recalling or reporting information incorrectly.
We wanted to isolate the property of genetic variation to improve our confidence in drawing conclusions about the relationship between BMI and cardiovascular health in a population of healthy young people.
Our results support the idea that having a healthy, normal BMI from a young age is likely to maintain a healthy cardiovascular system and help prevent heart disease later in life. Modern genetics allow us to investigate the causes of disease more quickly and cheaply than ever before, and the availability of genetic data in studies such as the Children of the 90s means we can more readily overcome limitations of traditional studies. We hope these findings lead to increased efforts to tackle the obesity epidemic at all stages of life, starting in early age.
As the NHS celebrates its 70th birthday, I hope that in another 58 years there will be similar celebrations and appreciation when its research arm, the National Institute for Health Research (NIHR), turns 70. Continue reading